mannich reaction and example

the compound which is capable to form enol mostly ketone and aldehyde when react with a mixture of formaldehyde or formalin who is 40% aqueous solution of formaldehyde and secondary Amine in the presence of acid or Lewis acid gives amino methyl derivative is called Mannich reaction.

mannich reaction  and example



Example:


1.amino methyl derivative or mannich base with ag2O gives alkene.
2. 
amino methyl derivative or mannich base with NaoEt gives alkene.
3.
amino methyl derivative or mannich base with NaCN gives cyanide then with stefan reagent gives aldehyde.


mannich reaction  and example


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