when the two Easter functional group present in same molecule having one Alpha hydrogen when treated with any base for example sodium ethoxide it will give cycclization reaction to from cyclic beta kero ester.
This reaction is known as dickmann condensation or intramolecular claisen ester condensation. To reduce carbon number in a cyclic compound we use this reaction.
Mechanism:
NaOEt is a strong base which captured one hydrogen from CH2 group and we get a nucleophilic centre which further attack carbonyl group of other ester and we get beta keto ester.
Comments
Post a Comment
If you have any quary regarding this blog please comment here.